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  • Identifying novel microenvironmental regulators
  • Developing new genetic models
  • Defining the role of altered niche
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Defining the role of altered niche in myelodysplastic syndromes

Concerted efforts to define the HSC bone marrow niche have pointed towards a functional role of many different cell types such as the osteoblasts, mesenchymal stromal cells, endothelial cells and the perivascular CAR cells. The significant interest in defining the microenvironment of HSCs has sparked research on defining the niche of hematological disorders that arise from these cells, such as Myelodysplastic Syndromes (MDS) and AML (Acute Myeloid Leukemia). In this context, our earlier work has shown that CD98-mediated adhesive interactions of leukemic stem cells with the endothelium are essential in sustaining these aggressive AML stem cell populations (Bajaj et al., Cancer Cell, 2016). Since the bone marrow microenvironment is known to be altered in MDS, and microenvironmental support is particularly important for MDS cell survival, it is likely that the leukemia-niche interactions that are important for AML growth also play a role in MDS progression. We are thus interested in defining the molecular effectors of these microenvironmental interactions and establishing their role in MDS progression using a combination of human MDS cells, genetic murine models and high-resolution in vivo imaging.

Complete list of Dr. Bajaj’s publications

wilmot cancer center

Jeevisha Bajaj, PhD

Assistant Professor
Department of Biomedical Genetics
Wilmot Cancer Institute
University of Rochester Medical Center
585.276.7140
Jeevisha_Bajaj@urmc.rochester.edu

Affiliations

Department of Biomedical Genetics

Genetics, Development, and Stem Cells Ph.D. Program

Wilmot Cancer Institute

University of Rochester Medical Center

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